During the Summer of 2015, I worked as a research assistant with the Biophotinics Imaging Laboratory. I received the opportunity to stay back over the summer and work as a research intern because of a class I took -- ENG 198 JS2 'Introduction to Research'. From the choices I had for what I wanted to work on over the summer, I chose this one because it closely related to Diagnostics. My parents are both doctors and some part of me was always fascinated by medical sciences. I wanted to give this a try and see where it lead.
Basically, the goal of the research is to quantify the mechanical properties of materials (industrial materials or biological samples). While most nano indentation instruments are extremely expensive, this research intended to replace it with an imaging device named optical coherence tomography (OCT) which has a significantly lower cost.
OCT can be regarded as a optical analogue of ultrasound, while OCT has higher resolution (micron meter scale) and sensitivity (nm scale) but smaller penetration depth (~2mm). One application of OCT is a field called optical coherence elastography (OCE), which utilizes OCT to detect the mechanical response of the sample upon perturbation. Therefore, the mechanical properties can be obtained. Many approaches have been proposed for OCE (in-contact or non-contact force excitation, static or dynamic mechanical response, etc). In this study, magnetomotive OCE (MM-OCE) was used, where we have a non-contact force excitation induced by an alternating magnetic field and we are typically looking at the dynamic response such as resonance frequency or shear wave propagation velocity.
In the paper, a steel microbead was placed on the sample and served as the force excitation source. The displacement response of the sample can be imaged through OCT, and then the displacement spectrum can be obtained and hence the resonant frequency (which reflects the mechanical property of the sample).
My work involved reading the research papers and understanding what the actual research was about. That took up a majority of my time. Understanding parts of the research without any background in the topic was a challenge. After that I summarized what I understood in my own terms and confirmed it with the Graduate student I was working under. Finally my contribution to the project was designing simulations in a software called COMSOL Multiphysics. The video on the left is a clip from the start of my project. Even this involved reading a lot of documentation and understanding how the software actually works and how to use it to the benefit of the research.
It was a productive summer because I can finally confirm that my interests don't lie in biosciences and I can finally move on.